Sunday, January 5, 2020

Human Aging And Cognition And Memory Storage - 869 Words

(A) SIGNIFICANCE: Despite the advances in our understanding of aging [1,2,3,4], the physiological and molecular correlates of aging-dependent alterations in specific neurons that underlie learning and memory storage are poorly understood. Such information is essential to delineate molecular underpinnings of aging-related changes to develop novel strategies for therapeutic intervention of the aging-associated specific deficits in learning and memory storage. Our proposed studies are highly significant to the studies on human aging and cognition in three major ways. (1) This proposal is highly relevant to human learning because of the focus on mechanisms of aging dependent changes in learning using a simple, but well characterized neural circuitry - the gill withdrawal reflex (GWR) of Aplysia. It is important to recognize that many concepts that are central to our overall understanding of learning and memory were established using Aplysia. For instance, the role of the cAMP signaling s ystem, or branch-specific storage of memories discovered in Aplysia has also been shown to be important in Drosophila and the mouse [5]. Therefore, it is expected that contributions of the proposed studies on aging will be conserved in mammals. (2) Because of two main reasons studying aging using defined synapses is critical for identifying specific cellular and molecular mechanisms of aging associated memory decline. First, studies using populations of neurons will dilute the specific changesShow MoreRelatedEssay on Does schema affect our memory?1326 Words   |  6 Pagesabilities are innate and that includes memory. Memory is tightly connected with learning, which then can be influenced the individuals behavior in the future. In terms of cognition, the psychologist focuses on the way we process information. 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